Artificial Intelligence (AI) has become commonplace to solve routine everyday tasks. Because of the exponential growth in medical imaging data volume and complexity, the workload on radiologists is steadily increasing. We project that the gap between the number of imaging exams and the number of expert radiologist readers required to cover this increase will continue to expand, consequently introducing a demand for AI-based tools that improve the efficiency with which radiologists can comfortably interpret these exams. AI has been shown to improve efficiency in medical-image generation, processing, and interpretation, and a variety of such AI models have been developed across research labs worldwide. However, very few of these, if any, find their way into routine clinical use, a discrepancy that reflects the divide between AI research and successful AI translation. To address the barrier to clinical deployment, we have formed MONAI Consortium, an open-source community which is building standards for AI deployment in healthcare institutions, and developing tools and infrastructure to facilitate their implementation. This report represents several years of weekly discussions and hands-on problem solving experience by groups of industry experts and clinicians in the MONAI Consortium. We identify barriers between AI-model development in research labs and subsequent clinical deployment and propose solutions. Our report provides guidance on processes which take an imaging AI model from development to clinical implementation in a healthcare institution. We discuss various AI integration points in a clinical Radiology workflow. We also present a taxonomy of Radiology AI use-cases. Through this report, we intend to educate the stakeholders in healthcare and AI (AI researchers, radiologists, imaging informaticists, and regulators) about cross-disciplinary challenges and possible solutions.

In order to assist the drug discovery/development process, pharmaceutical companies often apply biomedical NER and linking techniques over internal and public corpora. Decades of study of the field of BioNLP has produced a plethora of algorithms, systems and datasets. However, our experience has been that no single open source system meets all the requirements of a modern pharmaceutical company. In this work, we describe these requirements according to our experience of the industry, and present Kazu, a highly extensible, scalable open source framework designed to support BioNLP for the pharmaceutical sector. Kazu is a built around a computationally efficient version of the BERN2 NER model (TinyBERN2), and subsequently wraps several other BioNLP technologies into one coherent system. KAZU framework is open-sourced: https://github.com/AstraZeneca/KAZU

目的：本研究评估了市售可解释的AI算法在增强临床医生在胸部X射线（CXR）上鉴定肺癌的能力的影响。设计：这项回顾性研究评估了11位临床医生在胸部X光片中检测肺癌的表现，并在有和没有市售的AI算法的帮助下（红点，观察到），预测CXRS可疑的肺癌。根据临床确定的诊断评估了临床医生的表现。设置：该研究分析了NHS医院的匿名患者数据；该数据集由成年患者（18岁及以上）的400张胸部X光片组成，他们在2020年进行了CXR，并提供相应的临床文本报告。参与者：由11位临床医生（放射科医生，放射科医生受训者和报告射线照相师）组成的读者小组参加。主要结果指标：临床医生在CXR上检测肺癌的总体准确性，敏感性，特异性和精度，有或没有AI输入。还评估了有或没有AI输入的临床医生与绩效标准偏差之间的协议率。结果：临床医生对AI算法的使用导致肺部肿瘤检测的总体性能提高，从而达到了在CXR上鉴定出的肺癌的总体增长17.4％ ，分别增加了13％和13％的阶段1和2期肺癌的检测，以及临床医生表现的标准化。结论：这项研究在AI算法的临床实用性方面表现出了巨大的希望，可以通过整体改善读者表现来改善早期肺癌诊断和促进健康平等，而不会影响下游成像资源。

语言模型既展示了定量的改进，又展示了新的定性功能，随着规模的增加。尽管它们具有潜在的变革性影响，但这些新能力的特征却很差。为了为未来的研究提供信息，为破坏性的新模型能力做准备，并改善社会有害的效果，至关重要的是，我们必须了解目前和近乎未来的能力和语言模型的局限性。为了应对这一挑战，我们介绍了超越模仿游戏基准（Big Bench）。 Big Bench目前由204个任务组成，由132家机构的442位作者贡献。任务主题是多样的，从语言学，儿童发展，数学，常识性推理，生物学，物理学，社会偏见，软件开发等等。 Big-Bench专注于被认为超出当前语言模型的功能的任务。我们评估了OpenAI的GPT型号，Google内部密集变压器体系结构和大型基础上的开关稀疏变压器的行为，跨越了数百万到数十亿个参数。此外，一个人类专家评估者团队执行了所有任务，以提供强大的基准。研究结果包括：模型性能和校准都随规模改善，但绝对的术语（以及与评估者的性能相比）；在模型类中的性能非常相似，尽管带有稀疏性。逐渐和预测的任务通常涉及大量知识或记忆成分，而在临界规模上表现出“突破性”行为的任务通常涉及多个步骤或组成部分或脆性指标；社交偏见通常会随着含糊不清的环境而随着规模而增加，但这可以通过提示来改善。

当前在提取问题答案（EQA）中进行的研究对单跨度提取设置进行了建模，其中单个答案跨度是可以预测给定问题对对的标签。对于通用域EQA来说，这种设置是自然的，因为可以单个跨度可以回答通用域中的大多数问题。遵循通用域EQA模型，当前的生物医学EQA（BIOEQA）模型利用单跨度提取设置，采用后处理步骤。在本文中，我们调查了整个普通和生物医学领域的问题分布，发现生物医学问题更可能需要列表型答案（多个答案），而不是Factoid-type答案（单个答案）。这需要能够为问题提供多个答案的模型。基于这项初步研究，我们为Bioeqa提出了一种序列标记方法，Bioeqa是一种多跨度提取设置。我们的方法直接以不同数量的短语作为答案来解决问题，并可以学会从培训数据中确定问题的答案数量。我们在BioASQ 7B和8B列表类型问题上的实验结果优于表现最佳的现有模型，而无需进行后处理步骤。源代码和资源可免费下载，网址为https://github.com/dmis-lab/seqtagqa

There are multiple scales of abstraction from which we can describe the same image, depending on whether we are focusing on fine-grained details or a more global attribute of the image. In brain mapping, learning to automatically parse images to build representations of both small-scale features (e.g., the presence of cells or blood vessels) and global properties of an image (e.g., which brain region the image comes from) is a crucial and open challenge. However, most existing datasets and benchmarks for neuroanatomy consider only a single downstream task at a time. To bridge this gap, we introduce a new dataset, annotations, and multiple downstream tasks that provide diverse ways to readout information about brain structure and architecture from the same image. Our multi-task neuroimaging benchmark (MTNeuro) is built on volumetric, micrometer-resolution X-ray microtomography images spanning a large thalamocortical section of mouse brain, encompassing multiple cortical and subcortical regions. We generated a number of different prediction challenges and evaluated several supervised and self-supervised models for brain-region prediction and pixel-level semantic segmentation of microstructures. Our experiments not only highlight the rich heterogeneity of this dataset, but also provide insights into how self-supervised approaches can be used to learn representations that capture multiple attributes of a single image and perform well on a variety of downstream tasks. Datasets, code, and pre-trained baseline models are provided at: https://mtneuro.github.io/ .

Rigorous guarantees about the performance of predictive algorithms are necessary in order to ensure their responsible use. Previous work has largely focused on bounding the expected loss of a predictor, but this is not sufficient in many risk-sensitive applications where the distribution of errors is important. In this work, we propose a flexible framework to produce a family of bounds on quantiles of the loss distribution incurred by a predictor. Our method takes advantage of the order statistics of the observed loss values rather than relying on the sample mean alone. We show that a quantile is an informative way of quantifying predictive performance, and that our framework applies to a variety of quantile-based metrics, each targeting important subsets of the data distribution. We analyze the theoretical properties of our proposed method and demonstrate its ability to rigorously control loss quantiles on several real-world datasets.

The broad usage of mobile devices nowadays, the sensitiveness of the information contained in them, and the shortcomings of current mobile user authentication methods are calling for novel, secure, and unobtrusive solutions to verify the users' identity. In this article, we propose TypeFormer, a novel Transformer architecture to model free-text keystroke dynamics performed on mobile devices for the purpose of user authentication. The proposed model consists in Temporal and Channel Modules enclosing two Long Short-Term Memory (LSTM) recurrent layers, Gaussian Range Encoding (GRE), a multi-head Self-Attention mechanism, and a Block-Recurrent structure. Experimenting on one of the largest public databases to date, the Aalto mobile keystroke database, TypeFormer outperforms current state-of-the-art systems achieving Equal Error Rate (EER) values of 3.25% using only 5 enrolment sessions of 50 keystrokes each. In such way, we contribute to reducing the traditional performance gap of the challenging mobile free-text scenario with respect to its desktop and fixed-text counterparts. Additionally, we analyse the behaviour of the model with different experimental configurations such as the length of the keystroke sequences and the amount of enrolment sessions, showing margin for improvement with more enrolment data. Finally, a cross-database evaluation is carried out, demonstrating the robustness of the features extracted by TypeFormer in comparison with existing approaches.

Analogical proportions compare pairs of items (a, b) and (c, d) in terms of their differences and similarities. They play a key role in the formalization of analogical inference. The paper first discusses how to improve analogical inference in terms of accuracy and in terms of computational cost. Then it indicates the potential of analogical proportions for explanation. Finally, it highlights the close relationship between analogical proportions and multi-valued dependencies, which reveals an unsuspected aspect of the former.

Algorithms that involve both forecasting and optimization are at the core of solutions to many difficult real-world problems, such as in supply chains (inventory optimization), traffic, and in the transition towards carbon-free energy generation in battery/load/production scheduling in sustainable energy systems. Typically, in these scenarios we want to solve an optimization problem that depends on unknown future values, which therefore need to be forecast. As both forecasting and optimization are difficult problems in their own right, relatively few research has been done in this area. This paper presents the findings of the ``IEEE-CIS Technical Challenge on Predict+Optimize for Renewable Energy Scheduling," held in 2021. We present a comparison and evaluation of the seven highest-ranked solutions in the competition, to provide researchers with a benchmark problem and to establish the state of the art for this benchmark, with the aim to foster and facilitate research in this area. The competition used data from the Monash Microgrid, as well as weather data and energy market data. It then focused on two main challenges: forecasting renewable energy production and demand, and obtaining an optimal schedule for the activities (lectures) and on-site batteries that lead to the lowest cost of energy. The most accurate forecasts were obtained by gradient-boosted tree and random forest models, and optimization was mostly performed using mixed integer linear and quadratic programming. The winning method predicted different scenarios and optimized over all scenarios jointly using a sample average approximation method.